25 hydroxy cholecalciferol

25-hydroxy Vitamin D3
HIGH D3
Cholecalciferol is an inactivated form of vitamin D3 that has undergone various levels of hydroxylation to form an active vitamin D3 analogue. 1α -hydroxyvitamin D3 (α -calcitol) is a synthetic analogue metabolized to 1, 25-dihydroxycholecalciferol (the bioactive form of vitamin D3). Other analogues of cholecalciferol can be produced by different hydroxylation. 25-dihydroxycholecalciferol is the main circulating form of vitamin D3 and is the physiological precursor of 1α, 25-dihydroxycholecalciferol. This transformation is catalyzed by the 25-hydroxyvitamin D3 1-α -hydroxylase (VD3 1A hydroxylase), also known as cytochrome P450 27B1 (CYP27B1).

The research progress of 25- hydroxycholecalciferol (25-OH D) in animal nutrition, especially poultry, was reviewed. 25-OH DJ can improve the growth performance of broilers, but its effect is affected by the basal dietary calcium, phosphorus and vitamin D levels. 25-OH D can improve bone quality and reduce the incidence of tibial chondroplasia (TD), but this effect is affected by the genetic background of birds. 25-OH D: Increases distal ileum phytate-phosphorus digestibility without affecting intestinal (endogenous) phytase activity. 25-OH Ds regulates intestinal structure and immunity. 25-hydroxyD can improve eggshell quality of older laying hens. Based on bone mineralization and eggshell quality, 25-OH D was 1 to 2.5 times more effective than vitamin D. 25-OH D is 5 to 10 times more toxic than vitamin D in terms of kidney calcification.